Pro-Cure developed as a spin-out of the University of York, founded to translate the work of Professor Norman Maitland, Dr Anne Collins and their team in the YCR Cancer Research Unit. With an initial focus on prostate cancer – the particular cancer type where Professor Maitland and his team have become renowned as world leaders – Pro-Cure has established major research tools, competencies, methodologies and intellectual property for the study of primary human CSCs. From this base we have identified several hundred genes which are differentially regulated in the cancer stem cells and which form the basis of our target validation and drug development.